Macular degeneration is the leading cause of blindness in the US and most Western countries, affecting over 10 million Americans.  About a million Americans have the advanced wet form of macular degeneration which accounts for most vision loss.  The AREDS studies showed some mild benefit for macular degeneration, but this large study on B vitamin supplementation showed significant benefit for early macular degeneration patients in terms of reducing progression to the wet form.  Adding a combination of folate, Vitamin B12, and Vitamin B6 seemed to dramatically reduce progression in women with heart disease or heart disease risk factors.  It's a very interesting study and worthy of follow-up in a full clinical trial.